Holosystolic Murmurs

Holosystolic Murmur Introduction.

A holosystolic murmur, also called a pansystolic murmur, begins immediately after the first heart sound (S1) and continues to the second heart sound (S2), as illustrated in the phonocardiogram. Typically high-pitched, these murmurs are usually caused by ventricular septal defect, mitral regurgitation or tricuspid regurgitation, as discussed below.
holosystolic murmur

Ventricular Septal Defect

Ventricular Septal Defect (VSD) is a congenital condition associated with abnormal blood flow between the left ventricle and the right ventricle due to a shunt (hole) in the wall that separates the right and left ventricles. Holosystolic murmurs can be auscultated over the left 3rd and 4th intercostal spaces and along the sternal border.

Our reference guide for a holosystolic murmur caused by ventricular septal defect: Ventricular Septal Defect Lesson


Audio Playback

patient thorax when auscultating by stethoscope

patient position during auscultation
The patient was supine during auscultation.


Respiratory Sounds Reference Guide

Our auscultation reference guide provides quick access to holosystolic (pansystolic) sounds as well as many other adventitious sounds. Each sound is described also with an audio recording and waveform.

Related Lessons

Authors and Sources

Authors and Reviewers


? v:1 | onAr:0 | onPs:2 | tLb:0 | pv:1
uStat: False | db:0 | cc: | tar: False
| cDbLookup # 0 | pu: False | pl: System.Collections.Generic.List`1[System.String]

An error has occurred. This application may no longer respond until reloaded. Reload 🗙